Name | nordihydroguaiaretic acid |
Synonyms | NDGA, Larrea divaricata dihydronorguaiareticacid dihydro-norguaiareticaci nordihydroguaiaretic acid Dihydronorguaiaretic acid dihydro-dinorguaiareticaci Dinorguaiaretic acid, dihydro- 4,4-(2,3-Dimethyltetramethylene)dipyrocatechol 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane 4,4'-(2,3-dimethyltetramethylene)di-pyrocatecho Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl- 4,4'-[(2S,3S)-2,3-dimethylbutane-1,4-diyl]dibenzene-1,2-diol 4,4'-[(2R,3R)-2,3-dimethylbutane-1,4-diyl]dibenzene-1,2-diol beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane |
CAS | 500-38-9 |
EINECS | 207-903-0 |
InChI | InChI=1/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12-/m1/s1 |
Molecular Formula | C18H22O4 |
Molar Mass | 302.36 |
Density | 1.0772 (rough estimate) |
Melting Point | 184-186 °C (lit.) |
Boling Point | 363.4°C (rough estimate) |
Flash Point | 247.9°C |
Water Solubility | slightly soluble |
Solubility | Insoluble in water. Slightly soluble in hot water. Soluble in ethanol, ether, glycerin, propylene glycol. About 0.5% dissolved in grease. |
Vapor Presure | 1.06E-11mmHg at 25°C |
Appearance | White to off-white powder |
Color | White to off-white |
Merck | 14,6693 |
BRN | 2056825 |
pKa | 9.56±0.10(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Stability | Stable. Incompatible with oxidizing agents. |
Refractive Index | 1.4230 (estimate) |
MDL | MFCD00002206 |
Physical and Chemical Properties | White to off-white crystalline powder. The melting range was 183-185 ℃. Insoluble in water. Slightly soluble in hot water. Soluble in ethanol, ether, glycerol, propylene glycol. About 0.5% dissolved in oil. The antioxidant effect is good, and it is also effective against mildew. It has synergistic effect with citric acid and ascorbic acid. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
WGK Germany | 3 |
RTECS | UX1750000 |
HS Code | 29072990 |
Reference Show more | Evaluation of antioxidant and anti-inflammatory activities in vitro of three Solanum nigrum fruit extracts [J]. Modern Food Science and Technology, 2020, v.36;No.246(02):100-107. |